Association between DPYD c.1129-5923 C>G/hapB3 and severe toxicity to 5-fluorouracil-based chemotherapy in stage III colon cancer patients: NCCTG N0147 (Alliance)
- Citation:
- Pharmacogenet Genomics vol 26 (3) 133-137
- Year:
- 2016
- Type:
- Manuscript
- Funding:
- NCTN
- Endpoint:
- Secondary
- Analysis:
- Primary
- Data Sharing:
- No-Data-Sharing
- Status:
- Presented/Published
- Citation Status:
- pmc-release
- Note:
- Methodological:
- No
- Biospecimen:
- Yes
- SDC:
- No
- Book Volume:
- 5
- Parents:
- 2208
- Children:
- None
- Program:
- TRP
- Primary Committee:
- Correl Sci NOS
- Sec. Committees:
- GI
- Pharmas:
- Grants:
- U10 CA180868, UG1 CA189867, R01CA062164, U10CA31946, R01CA116964, U10 CA180835, U10 CA031946, U10 CA033601, K05CA142885, U10 CA180821, U24 CA114740, U10 CA180850, R01 CA116964, U10 CA180790, P30 CA015083, U10CA33601, U24CA114740, R01 CA062164, U10 CA180867, K05 CA142885, U10 CA180888
- Corr. Author:
- Adam M. Lee
- Authors:
- Adam M. Lee Qian Shi Steven R. Alberts Daniel J. Sargent Frank A. Sinicrope Jeffrey L. Berenberg Axel Grothey Blase Polite Emily Chan Sharlene Gill Morton S. Kahlenberg Suresh G. Nair Anthony F. Shields Richard M. Goldberg Robert B. Diasio
- Networks:
- HAWAII, LAPS-IL057, LAPS-MN026, LAPS-OH007, MCRC, MS012
- Study
- NCCTG-N0147
- Multiple Studies, or Legacy Studies in Alliance Study:
- Phases:
- 3
- Keywords:
- dihydropyrimidine dehydrogenase, polymorphism, pharmacogenetics, 5-fluorouracil, colon cancer, toxicity