Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism That Increases Risk of Docetaxel-Induced Neuropathy
- Citation:
- Clin Cancer Res vol 22 (19) 4890-900
- Year:
- 2016
- Type:
- Manuscript
- Funding:
- NCTN
- Endpoint:
- Primary
- Analysis:
- Primary
- Data Sharing:
- No-Data-Sharing
- Status:
- Presented/Published
- Citation Status:
- ppub
- Note:
- Pharmas:
- Genentech
- Grants:
- U10 CA047577, P30 NR014129, U01 GM061393, U10 CA180802, U10 CA021115, U10 CA031946, U10 CA033601, U10 CA180821, P30 CA008748, U10 CA180791, U10 CA180857, U01 GM061390, U10 CA016116, R01 NS064015, U10 CA180820, U10 CA180867, U10 CA180838
- Corr. Author:
- Authors:
- Daniel L. Hertz Kouros Owzar Sherrie Lessans Claudia Wing Chen Jiang William Kevin Kelly Jai Patel Susan Halabi Yoichi Furukawa Heather E. Wheeler Alexander B. Sibley Cameron Lassiter Lois Weisman Dorothy Watson Stefanie D. Krens Flora Mulkey Cynthia L. Renn Eric J. Small Phillip G. Febbo Ivo Shterev Deanna L. Kroetz Paula N. Friedman John F. Mahoney Michael A. Carducci Michael J Kelley Yusuke Nakamura Michiaki Kubo Susan G. Dorsey M. Eileen Dolan Michael J. Morris Mark J. Ratain Howard L. McLeod
- Networks:
- CA824, LAPS-IL036, LAPS-IL057, LAPS-MA036, LAPS-MD017, LAPS-MN026, LAPS-NC007, LAPS-NY016, NC002
- Study
- CALGB-60404
- Multiple Studies, or Legacy Studies in Alliance Study:
- CALGB-90401
- Phases:
- N/A, 3
- Keywords:
- docetaxel, paclitaxel, pharmacogenetics, genome-wide association study, heritability, single nucleotide polymorphism, chemotherapy-induced peripheral neuropathy, VAC14, peripheral neuronal cell model, animal model